There is a global restriction (listed under the relics section) stating that they are unique within the army:However, you're still bounded by the rules for purchasing items according to your army list. In the Space Marines Wargear list, each section specifies what must be traded out when purchasing a piece of equipment. Most sections specify that they can trade either weapon with an and/or clause. However, the subsection for relics contains the line Brandon quoted on page 159:The sacred artefacts of the Adeptus Astartes are items of incredible rarity. Only one of each of the following items may be chosen per army – there is only one of each of these items in the galaxy.It's also worth noting that special weapons include a similar clause (just an or - not and/or), meaning the 4 flamer / 4 melta command squad would no longer be legal.Only one of each Chapter Relic may be taken per army. A model can replace one weapon with one of the following: