The Dragon's Lair would probably also be the best choice for off night gaming as well. While non of the people I've run into from any store seem the type to try and force you to play a game on that game's specific night, Dragon's Lair now has quite a bit more space than the other stores (10th Planet in particular seems that it would run out of space very quickly. The few nights I've gone in there every table was taken over). I frequently see a game or two of 40K popping up on some of the tables on Wednesday night for example. Being a Warmahordes/Malifaux player I can't personally vouch for the 40K crowd, except for the couple who play my games as well, who are generally hardcore, but not exclusionary or clique-ish. Con season can get a little rough for casual games as everyone gets a little more competitive and starts to tweak their "killer army," but you should always be able to find someone laid back.